Study of Thyroid Auto-Antibodies in Patients with Bronchial Asthma and Allergic Rhinitis

Abstract

Background: Authors of a few reports have stated that autoimmunity increases the frequency of Grave’s disease in some patients with allergic rhinitis. Also, seasonal allergic rhinitis has been reported to be more frequent in Grave’s disease but rare in painless thyroiditis. However, little is known about the relation between thyroid disease and allergic diseases. Aim of Our Work: Our aim was to study the coexistence of thyroid auto-antibodies in patients with bronchial asthma and allergic rhinitis. Methods: Forty patients with allergic diseases (20 patients with bronchial asthma [BA] and 20 patients with allergic rhinitis [AR]) and 20 3 healthy control subjects were included in the study. We measured the free triiodothyronine (FT ), free thyroxin 4 (FT ) by radioimmunoassay (RIA), and thyroid stimulating hormone (TSH); thyroid auto-antibodies (antithyroid peroxidase [anti-TPO] and anti-thyroglobulin [anti-TG]) by Enzyme-linked Immunosorbent Assay (ELISA); the complete blood picture; allergic skin tests; and peak expiratory flow rate measured by spirometry. Results: Thyroid auto-antibodies levels were higher in patients with BA and AR compared to healthy subjects 3 4 (P < 0.05). However, thyroid function test results (FT , FT , and TSH) did not significantly differ between patients and controls. Also, thyroid auto-antibodies levels did not significantly differ between patients with BA and those with AR (P > 0.05). Conclusion: Thyroid auto-immunity was associated with allergic disease but was not reflected in changed thyroid biochemical profiles.

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